Summary: The immune-genetic changes that occur in cancer patients experiencing hyperprogressive disease (HPD) during combined immunotherapy are unclear.In this study, HPD patients with pre- and post-HPD samples and non-HPD patients with solid tumors were molecularly characterized by genetic and tumor immune microenvironment (TiME) analyses of Boxer
Trauma with an accompanying fracture to the anterior teeth gives an agonizing experience for Sculptures a young individual due to the physical disfigurement and the psychological impact that is imposed on them.This paper reports a case of complicated crown-root fracture in a young child that was treated by extra-oral fragment reattachment followed
Abstract Modelling insulin-glucose homeostasis may provide novel functional insights.In particular, simple models are clinically useful if Fryer Accessories they yield diagnostic methods.Examples include the homeostasis model assessment (HOMA) and the quantitative insulin sensitivity check index (QUICKI).However, limitations of these approaches hav
Land, water, and food resources are essential for human survival, economic development, and social stability.Water and land are the basic resources in irrigated agricultural systems.Sustainable agricultural development entails effective management of the land-water-food nexus.The complex relationship in land-water-food nexus, with large uncertainti
This paper was aimed at the techno-economic feasibility assessment of a 25 MW solar photovoltaic (PV) system for electricity generation in Effurun-Warri, Nigeria.The system advisor model (SAM) software was used to design and simulate the solar PV modules for power generation.Furthermore, the standard and validated models inbuilt in the SAM software